Indirect factor Xa inhibitor ( relatively selective). Narrow therapeutic window and highly variable dose–response curve Monitor-aPTT (1.5–2.5× normal) and platelets Heparin resistance is usually due to AT deficiency and could be treated with AT concentratesįor acute clot, unfractionated heparin 80 U/kg or 5,000 U IV bolus, then 18 U/kg/h or 1,000 U/h, and adjustto 1.5–2.5× normal PTTįor DVT prophylaxis, unfractionated heparin 5,000U SC 2 h before surgery, then 5,000U SC TIDĬomplications-bleeding (may be reversed by protamine 1 mg/100 U UFH), HITT, osteoporosis Binds to antithrombin (AT) and converts it from a slow form to fast-acting form, which binds and inactivates thrombin and factors Xa, IXa, XIa, XIIa Indirect thrombin and factor Xa inhibitor ( nonselective). Warfarin 5 mg PO daily overlapping with heparin for 5 days, then adjust based on INR target of 2–3Ĭomplications-bleeding (may be reversed with vitamin K), coumadin-induced skin necrosis Inhibits hepatic synthesis of vitamin K-dependent factors (II, VII, IX, X, protein S, protein C) Nephron 16(1):31-41.Inhibition of gamma carboxylation by inhibition of the vitamin K-dependent epoxide reductase. (1976) Prediction of creatinine clearance from serum creatinine. J Clin Oncol 7:1748-1756.Ģ) Cockcroft DW, Gault MH. (1989) Carboplatin dosage: prospective evaluation of a simple formula based on renal function. Referencesġ) Calvert AH, Newell DR, Gumbrell LA, et al. When using the creatinine clearance estimation there is also the consideration to be made that fluctuant serum creatinine values should not be taken in consideration because they don’t provide reliable results employed later in estimating GFR and in the Calvert formula. Target AUC usually has values around 4-7 mg/ml/min in clinical practice for already treated patients but for those without previous chemotherapy sessions the target should revolve around 6-8 mg/ml/min. This is said to be a more specific method than that of dosing based on body surface area. The carboplatin dosage value is calculated by taking into account the target area concentration versus time curve and estimated GFR. ■Carboplatin dose based on the Calvert formula is:ĭosage = Target AUC x (GFR + 25) Carboplatin and target AUC ■ The calculation of the ideal body weight by Devine’s formula: ■ If the serum creatinine is expressed in µmol/L then:ĬrCl for male = / (Serum Creatinine in µmol/L)ĬrCl for female = / (Serum Creatinine in µmol/L) ■ If the serum creatinine is expressed in mg/dL Cockcroft and Gault equation is:ĬrCl for male = / (Serum Creatinine in mg/dL * 72)ĬrCl for female = / (Serum Creatinine in mg/dL * 72) Here are the formulas that use your data: Where needed the results will be converted in both types of units for your convenience, for instance at ideal weight by Devine’s formula (from kg to lbs using 1 kg = 2.20462262 lbs). This Carboplatin AUC calculator will then retrieve you some useful indicators about the kidney function, the GFR value, the ideal weight and the total dosage required in the used case. There are fields that you need to complete for the results to be consistent such as the gender, age, weight and height in either metric or English measurements and the serum creatinine level either in mg/dL or µmol/L. This is a health tool that allows you to compute the total Carboplatin dose in mg based on the estimated creatinine clearance level from the Cockcroft Gault equation and on the targeted AUC value. How does this Carboplatin AUC calculator work?
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